Differential diagnosis with CD30-positive lymphoproliferative disorders

In addition to being an excellent marker for Reed-Sternberg cells, T-cell lymphomas and variants, CD30 expression can be seen in the cutaneous CD30-positive lymphoproliferative disorders, LyP and primary cALCL.1

CD30-positive lymphoproliferative disorders constitute a clinical-pathologic spectrum, with LyP and ALCL at either end. Between them fall unclassifiable cases in which the clinical and histologic features do not allow clear differentiation between the two.2 This diagnostic algorithm for CD30-positive lesions was modified by Calzado-Villarreal et al from one proposed by Bekkenk et al.

Primary cutaneous CD30-positive lymphoproliferative disorders2,3

Flowchart of primary cutaneous CD30-positive lymphoproliferative disorders


  1. Hsi ED, Yegappan S. Lymphoma immunophenotyping: a new era in paraffin-section immunohistochemistry. Adv Anat Pathol. 2001;8(4):218-239.
  2. Calzado-Villarreal L, Polo-Rodríguez I, Ortiz-Romero PL. Primary cutaneous CD30+ lymphoproliferative disorders [in Spanish]. Actas Dermosifiliogr. 2010;101(2):119-128.
  3. Bekkenk MW, Geelen FAMJ, van Voorst Vader PC, et al. Primary and secondary cutaneous CD30+ lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood. 2000;95(12):3653-3661.